3-(trifluoromethyl)-2-pyridinecarboxylic acid

3-(trifluoromethyl)-2-pyridinecarboxylic acid - Names and Identifiers

Name	3-(Trifluoromethyl)pyridine-2-carboxylic acid
Synonyms	3-(TRIFLUOROMETHYL)PICOLINIC ACID 3-(TRIFLUOROMETHYL)-2-PICOLINIC ACID 3-(Trifluoromethy)pyridine-2-carboxylic acid 3-(TRIFLUOROMETHYL)PYRIDINE-2-CARBOXYLIC ACID 3-(trifluoromethyl)-2-pyridinecarboxylic acid 3-(Trifluoromethyl)pyridine-2-carboxylic acid 2-Pyridinecarboxylic acid, 3-(trifluoromethyl)- 3-(Trifluoromethyl)-2-pyridinecarboxylicacid(en) 3-(Trifluoromethyl)picolinic acid, 2-Carboxy-3-(trifluoromethyl)pyridine
CAS	87407-12-3
InChI	InChI=1/C7H4F3NO2/c8-7(9,10)4-2-1-3-11-5(4)6(12)13/h1-3H,(H,12,13)

3-(trifluoromethyl)-2-pyridinecarboxylic acid - Physico-chemical Properties

Molecular Formula	C7H4F3NO2
Molar Mass	191.11
Density	1.484g/cm³
Melting Point	125-130°C
Boling Point	274.4°C at 760 mmHg
Flash Point	119.7°C
Solubility	DMSO (Slightly), Methanol (Slightly)
Vapor Presure	0.00264mmHg at 25°C
Appearance	Solid
Color	Off-White
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Refractive Index	1.475
MDL	MFCD07375386

3-(trifluoromethyl)-2-pyridinecarboxylic acid - Risk and Safety

Risk Codes	R25 - Toxic if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	2811
WGK Germany	3
Hazard Class	IRRITANT
Packing Group	Ⅲ

3-(trifluoromethyl)-2-pyridinecarboxylic acid - Introduction

3-(Trifluoromethyl)pyridine-2-carboxylic acid, the chemical formula is C≡H≡F≡NO₂.

Nature:
3-(Trifluoromethyl)pyridine-2-carboxylic acid is a colorless crystalline solid with special chemical properties. It has a melting point of about 122-126 degrees Celsius and a boiling point of 328 degrees Celsius. It is not volatile at room temperature.

Use:
3-(Trifluoromethyl)pyridine-2-carboxylic acid has a wide range of applications in the field of organic synthesis. It is often used as a catalyst, intermediate and raw material. It can participate in a variety of organic reactions, such as nucleophilic substitution reactions, addition reactions and the synthesis of carboxylic acid derivatives.

Preparation Method:
3-(Trifluoromethyl)pyridine-2-carboxylic acid has many synthetic methods, one of which is obtained by the reaction of 3-trifluoromethylpyridine and carbon dioxide. The specific step is that 3-trifluoromethylpyridine and carbon dioxide are reacted under heating conditions to generate 3-(Trifluoromethyl)pyridine-2-carboxylic acid. The synthetic methods generally require the use of catalysts, solvents and appropriate reaction conditions.

Safety Information:
3-(Trifluoromethyl)pyridine-2-carboxylic acid is generally relatively safe under proper use, but the following matters still need to be paid attention:
1. When handling the compound, care should be taken to avoid contact with skin, eyes or inhalation of its dust. Appropriate personal protective equipment such as gloves, glasses and masks should be worn.
2. should be stored in a cool and dry place, away from fire and oxidant, so as not to cause fire or explosion.
3. The compound may have a certain risk to the environment and should be handled and disposed of in accordance with relevant regulations.

Please note that the information provided above is for informational purposes only, reference should be made to the relevant literature on chemicals and chemical safety manuals, and the relevant environmental, health and safety guidelines should be strictly followed during the experiment.

Last Update：2024-04-10 22:29:15